Compound Detail
CHEMBL3261481
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Basic Information
| ChEMBL ID | CHEMBL3261481 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MBYAMJFNDALRJQ-OAHLLOKOSA-N |
2
Targets
4
Activities
2
Assay Types
1
PK Parameters
9
Publications
0
Known Names
Molecular Properties
296.4
MW (Da)
1.59
ALogP
4
HBA
0
HBD
41.4
PSA (Ų)
0.80
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 6.75
Ki 2 meas. best 8.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 3A CHEMBL1899 | Ki | 8.1 | 8.095 | 8.0 | 2 |
| 5-hydroxytryptamine receptor 3A CHEMBL1899 | EC50 | 6.75 | 6.75 | 178.0 | 1 |
| 5-hydroxytryptamine receptor 3A CHEMBL4972 | EC50 | 6.75 | 6.75 | 178.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 1.7 | mL.min-1.g-1 | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 3A | Ki | = | 8.0 | nM | 8.1 | Radioligand Binding Assay: The relative affinity of the various compounds for th... | - |
| 5-hydroxytryptamine receptor 3A | Ki | = | 8.1 | nM | 8.09 | Displacement of [9-methyl-3H]BRL-43694 from human 5-HT3A receptor after overnigh... | 24755431 |
| 5-hydroxytryptamine receptor 3A | EC50 | = | 178.0 | nM | 6.75 | Agonist activity at human 5-HT3A receptor expressed in HEK293 cells in presence ... | 24755431 |
| 5-hydroxytryptamine receptor 3A | EC50 | = | 178.0 | nM | 6.75 | Agonist activity at mouse 5-HT3A receptor expressed in HEK293 cells in presence ... | 24755431 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24755431 | 10.1016/j.bmcl.2014.03.074 | 5-hydroxytryptamine receptor 3A | 5 |
| 24755431 | 10.1016/j.bmcl.2014.03.074 | Cytochrome P450 1A2 | 1 |
| 24755431 | 10.1016/j.bmcl.2014.03.074 | Cytochrome P450 2B6 | 1 |
| 24755431 | 10.1016/j.bmcl.2014.03.074 | Cytochrome P450 2C9 | 1 |
| 24755431 | 10.1016/j.bmcl.2014.03.074 | Cytochrome P450 2C19 | 1 |
| 24755431 | 10.1016/j.bmcl.2014.03.074 | Cytochrome P450 2D6 | 1 |
| 24755431 | 10.1016/j.bmcl.2014.03.074 | Cytochrome P450 3A4 | 1 |
| 24755431 | 10.1016/j.bmcl.2014.03.074 | Liver microsome | 1 |
| 24755431 | 10.1016/j.bmcl.2014.03.074 | Mus musculus | 1 |
Data from ChEMBL 36 via Core Engine