Compound Detail
CHEMBL3262302
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Basic Information
| ChEMBL ID | CHEMBL3262302 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VBGROGMZFVASFY-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
407.5
MW (Da)
4.69
ALogP
6
HBA
0
HBD
65.7
PSA (Ų)
0.42
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.01
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A CHEMBL4409 | IC50 | 6.01 | 6.01 | 971.2 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | IC50 | = | 971.2 | nM | 6.01 | Inhibition of N-terminal GST-tagged human recombinant PDE10A assessed as substra... | 24725435 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24725435 | 10.1016/j.bmcl.2014.03.054 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 2 |
| 24725435 | 10.1016/j.bmcl.2014.03.054 | Liver microsome | 2 |
Data from ChEMBL 36 via Core Engine