Compound Detail
CHEMBL327614
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Basic Information
| ChEMBL ID | CHEMBL327614 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VAVPHXVLHKKEPH-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
457.6
MW (Da)
4.96
ALogP
7
HBA
1
HBD
94.3
PSA (Ų)
0.40
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.8
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Type-1 angiotensin II receptor B CHEMBL263 | IC50 | 5.8 | 5.775 | 1600.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Type-1 angiotensin II receptor B | IC50 | = | 1600.0 | nM | 5.8 | Displacement of [125-I]-labeled angiotensin II from Angiotensin II receptor, typ... | - |
| Type-1 angiotensin II receptor B | IC50 | = | 1800.0 | nM | 5.75 | Displacement of [125-I]-labeled angiotensin II from Angiotensin II receptor, typ... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(01)80290-0 | Type-1 angiotensin II receptor B | 2 |
Data from ChEMBL 36 via Core Engine