Compound Detail
CHEMBL329306
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Basic Information
| ChEMBL ID | CHEMBL329306 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HUOVVNDFQLHQOR-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
389.1
MW (Da)
5.38
ALogP
4
HBA
0
HBD
42.5
PSA (Ų)
0.64
QED
1
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.55
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Gamma-aminobutyric acid receptor subunit beta-3 CHEMBL1847 | IC50 | 7.55 | 7.55 | 28.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Gamma-aminobutyric acid receptor subunit beta-3 | IC50 | = | 28.0 | nM | 7.55 | Inhibition of [3H]EBOB binding to drosophila GABA-A receptor (range 1-28) | 11677140 |
| Gamma-aminobutyric acid receptor subunit beta-3 | IC50 | = | 28.0 | nM | 7.55 | Inhibition of [3H]EBOB binding to human GABA-A receptor beta3 subunit (range 1-2... | 11677140 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11677140 | 10.1016/s0960-894x(01)00604-7 | Gamma-aminobutyric acid receptor subunit beta-3 | 2 |
Data from ChEMBL 36 via Core Engine