Compound Detail
CHEMBL329732
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL329732 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OFWMOMTWUUKYMP-VWLOTQADSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
427.6
MW (Da)
3.82
ALogP
5
HBA
0
HBD
65.2
PSA (Ų)
0.52
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.44
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein farnesyltransferase CHEMBL2094108 | IC50 | 7.44 | 7.335 | 36.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein farnesyltransferase | IC50 | = | 36.0 | nM | 7.44 | Concentration required to displace 50% of a potent radiolabeled FTI from farnesy... | 11520202 |
| Protein farnesyltransferase | IC50 | = | 59.0 | nM | 7.23 | In vitro inhibition of farnesyl transferase using purified recombinant human enz... | 11520202 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11520202 | 10.1021/jm010156p | Protein farnesyltransferase | 2 |
Data from ChEMBL 36 via Core Engine