Compound Detail
CHEMBL331124
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Cc1nc2cnccc2n1-c1ccc(C2=Nc3c(-c4ccccc4)nn4c3N(CC4)C(=O)C2)cc1
Basic Information
| ChEMBL ID | CHEMBL331124 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MMQVOMOXNMJGMC-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
459.5
MW (Da)
4.46
ALogP
7
HBA
0
HBD
81.2
PSA (Ų)
0.40
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Platelet-activating factor receptor CHEMBL5136 | IC50 | 8.4 | 8.4 | 4.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Platelet-activating factor receptor | IC50 | = | 4.0 | nM | 8.4 | In vitro antagonist activity against platelet activating factor (PAF) receptor, ... | 7658439 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 7658439 | 10.1021/jm00018a012 | Platelet-activating factor receptor | 1 |
| 7658439 | 10.1021/jm00018a012 | Mus musculus | 1 |
Data from ChEMBL 36 via Core Engine