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Compound Detail

CHEMBL3314442

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COc1ccc(-n2nc(S(C)(=O)=O)c3c2C(=O)N(c2ccc(C(C)(C)CN(C)C)cc2)CC3)cc1

Basic Information

ChEMBL ID CHEMBL3314442
Phase Preclinical
Structure Type MOL
InChI Key FNSLVMWXSWYZKF-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
3
PK Parameters
4
Publications
0
Known Names

Molecular Properties

496.6
MW (Da)
3.33
ALogP
7
HBA
0
HBD
84.7
PSA (Ų)
0.50
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C26H32N4O4S
MW 496.63
Aromatic Rings 3
Heavy Atoms 35
NP-Likeness -1.08

Activity Summary

Ki 1 meas. best 9.96

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Coagulation factor X
CHEMBL244
Ki 9.96 9.96 0.1 1

Pharmacokinetic Data

Parameter Value Units Species
CL 64.33 mL.min-1.kg-1 Canis lupus familiaris
F 34.0 % Canis lupus familiaris
T1/2 1.86 hr Canis lupus familiaris

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Coagulation factor X Ki = 0.11 nM 9.96 Inhibition of purified human factor Xa 24951330

Literature References

PubMed DOI Target Context # Activities
24951330 10.1016/j.bmcl.2014.05.101 Canis familiaris 4
24951330 10.1016/j.bmcl.2014.05.101 Coagulation factor X 1
24951330 10.1016/j.bmcl.2014.05.101 ADMET 1
24951330 10.1016/j.bmcl.2014.05.101 Plasma 1

Data from ChEMBL 36 via Core Engine