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Compound Detail

CHEMBL3314443

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COc1ccc(-n2nc(S(C)(=O)=O)c3c2C(=O)N(c2ccc(C(C)(C)CN4CCCC4)cc2)CC3)cc1

Basic Information

ChEMBL ID CHEMBL3314443
Phase Preclinical
Structure Type MOL
InChI Key WHFAAZLHEKXVFF-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
3
PK Parameters
4
Publications
0
Known Names

Molecular Properties

522.7
MW (Da)
3.86
ALogP
7
HBA
0
HBD
84.7
PSA (Ų)
0.47
QED
1
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C28H34N4O4S
MW 522.67
Aromatic Rings 3
Heavy Atoms 37
NP-Likeness -1.07

Activity Summary

Ki 1 meas. best 9.62

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Coagulation factor X
CHEMBL244
Ki 9.62 9.62 0.2 1

Pharmacokinetic Data

Parameter Value Units Species
CL 36.67 mL.min-1.kg-1 Canis lupus familiaris
F 10.0 % Canis lupus familiaris
T1/2 1.4 hr Canis lupus familiaris

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Coagulation factor X Ki = 0.24 nM 9.62 Inhibition of purified human factor Xa 24951330

Literature References

PubMed DOI Target Context # Activities
24951330 10.1016/j.bmcl.2014.05.101 Canis familiaris 4
24951330 10.1016/j.bmcl.2014.05.101 Coagulation factor X 1
24951330 10.1016/j.bmcl.2014.05.101 ADMET 1
24951330 10.1016/j.bmcl.2014.05.101 Plasma 1

Data from ChEMBL 36 via Core Engine