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Compound Detail

CHEMBL3317474

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CC(=O)c1ccc(-c2nc3cccnc3[nH]2)cc1

Basic Information

ChEMBL ID CHEMBL3317474
Phase Preclinical
Structure Type MOL
InChI Key HRXUUBWDAGEVHF-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
10
Publications
0
Known Names

Molecular Properties

237.3
MW (Da)
2.83
ALogP
3
HBA
1
HBD
58.6
PSA (Ų)
0.70
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C14H11N3O
MW 237.26
Aromatic Rings 3
Heavy Atoms 18
NP-Likeness -1.12

Activity Summary

EC50 1 meas. best 4.19

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
NON-PROTEIN TARGET
CHEMBL3879801
EC50 4.19 4.19 65000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
NON-PROTEIN TARGET EC50 = 65000.0 nM 4.19 Antiviral activity against Bovine viral diarrhea virus 1-NADL ATCC VR-534 infect... 25014745

Literature References

PubMed DOI Target Context # Activities
25014745 10.1016/j.ejmech.2014.07.011 NON-PROTEIN TARGET 4
25014745 10.1016/j.ejmech.2014.07.011 ADMET 3
25014745 10.1016/j.ejmech.2014.07.011 Human immunodeficiency virus 1 1
25014745 10.1016/j.ejmech.2014.07.011 MT4 1
25014745 10.1016/j.ejmech.2014.07.011 Yellow fever virus 1
25014745 10.1016/j.ejmech.2014.07.011 Coxsackievirus B5 1
25014745 10.1016/j.ejmech.2014.07.011 Human poliovirus 1 strain Sabin 1
25014745 10.1016/j.ejmech.2014.07.011 Vesicular stomatitis Indiana virus 1
25014745 10.1016/j.ejmech.2014.07.011 Human alphaherpesvirus 1 1
27161176 10.1016/j.ejmech.2016.03.080 NON-PROTEIN TARGET 1

Data from ChEMBL 36 via Core Engine