Compound Detail
CHEMBL331907
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Basic Information
| ChEMBL ID | CHEMBL331907 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BULOMLIWEVCBPE-UHFFFAOYSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
403.5
MW (Da)
4.89
ALogP
7
HBA
0
HBD
65.2
PSA (Ų)
0.49
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 4 meas. best 8.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| GABA-A receptor; alpha-5/beta-3/gamma-2 CHEMBL2094122 | Ki | 8.4 | 8.4 | 4.0 | 1 |
| GABA-A receptor; alpha-3/beta-3/gamma-2 CHEMBL2094120 | Ki | 7.66 | 7.66 | 22.0 | 1 |
| GABA-A receptor; alpha-2/beta-3/gamma-2 CHEMBL2094130 | Ki | 7.18 | 7.18 | 66.0 | 1 |
| GABA-A receptor; alpha-1/beta-3/gamma-2 CHEMBL2094121 | Ki | 6.94 | 6.94 | 115.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| GABA-A receptor; alpha-5/beta-3/gamma-2 | Ki | = | 4.0 | nM | 8.4 | Binding affinity towards human alpha-5-beta-3-gamma-2 GABA-A receptor using [3H]... | 15214791 |
| GABA-A receptor; alpha-3/beta-3/gamma-2 | Ki | = | 22.0 | nM | 7.66 | Binding affinity towards human gamma-aminobutyric-acid A receptor alpha-3-beta-3... | 15214791 |
| GABA-A receptor; alpha-2/beta-3/gamma-2 | Ki | = | 66.0 | nM | 7.18 | Binding affinity towards human gamma-aminobutyric-acid A receptor alpha-2-beta-3... | 15214791 |
| GABA-A receptor; alpha-1/beta-3/gamma-2 | Ki | = | 115.0 | nM | 6.94 | Binding affinity towards human alpha-1-beta-3-gamma-2 GABA-A receptor using [3H]... | 15214791 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15214791 | 10.1021/jm0407613 | GABA-A receptor; alpha-5/beta-3/gamma-2 | 1 |
| 15214791 | 10.1021/jm0407613 | GABA-A receptor; alpha-1/beta-3/gamma-2 | 1 |
| 15214791 | 10.1021/jm0407613 | GABA-A receptor; alpha-2/beta-3/gamma-2 | 1 |
| 15214791 | 10.1021/jm0407613 | GABA-A receptor; alpha-3/beta-3/gamma-2 | 1 |
Data from ChEMBL 36 via Core Engine