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Compound Detail

CHEMBL3326996

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CCCOc1cc(O)c2c(=O)c(OCCC)c(-c3ccc(O)c(O)c3)oc2c1

Basic Information

ChEMBL ID CHEMBL3326996
Phase Preclinical
Structure Type MOL
InChI Key KEINNCRXIQMJRA-UHFFFAOYSA-N
6
Targets
8
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names

Molecular Properties

386.4
MW (Da)
4.15
ALogP
7
HBA
3
HBD
109.4
PSA (Ų)
0.52
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H22O7
MW 386.40
Aromatic Rings 3
Heavy Atoms 28
NP-Likeness 0.86

Activity Summary

IC50 8 meas. best 4.58

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
A549
CHEMBL392
IC50 4.58 4.58 26200.0 1
NCI-H1792
CHEMBL1075525
IC50 4.51 4.51 30610.0 1
NON-PROTEIN TARGET
CHEMBL3879801
IC50 4.51 4.49 31050.0 3
NCI-H157
CHEMBL614783
IC50 4.39 4.39 40910.0 1
HeLa
CHEMBL399
IC50 4.33 4.33 47030.0 1
HOP-62
CHEMBL614643
IC50 4.33 4.33 47230.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

Data from ChEMBL 36 via Core Engine