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Compound Detail

CHEMBL3327002

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CCCOc1cc(O)c2c(=O)c(OCCC)c(-c3ccc(OCCC)c(O)c3)oc2c1

Basic Information

ChEMBL ID CHEMBL3327002
Phase Preclinical
Structure Type MOL
InChI Key CYRMKUHOVQAPBC-UHFFFAOYSA-N
5
Targets
9
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names

Molecular Properties

428.5
MW (Da)
5.24
ALogP
7
HBA
2
HBD
98.4
PSA (Ų)
0.46
QED
1
Ro5 Violations
10
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C24H28O7
MW 428.48
Aromatic Rings 3
Heavy Atoms 31
NP-Likeness 0.69

Activity Summary

IC50 9 meas. best 5.32

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
NON-PROTEIN TARGET
CHEMBL3879801
IC50 5.32 4.748 4750.0 5
HeLa
CHEMBL399
IC50 4.89 4.89 12860.0 1
A549
CHEMBL392
IC50 4.73 4.73 18590.0 1
M14
CHEMBL614317
IC50 4.47 4.47 33970.0 1
HOP-62
CHEMBL614643
IC50 4.44 4.44 36040.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

Data from ChEMBL 36 via Core Engine