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Compound Detail

CHEMBL334690

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CN(CCCCCCCCN(C)C(=O)CCCCCNCCC(=O)N1c2ccccc2C(=O)Nc2cccnc21)C(=O)CCCCCN

Basic Information

ChEMBL ID CHEMBL334690
Phase Preclinical
Structure Type MOL
InChI Key CKHJLNLEHGUDID-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

663.9
MW (Da)
5.63
ALogP
7
HBA
3
HBD
141.0
PSA (Ų)
0.13
QED
2
Ro5 Violations
23
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C37H57N7O4
MW 663.91
Aromatic Rings 2
Heavy Atoms 48
NP-Likeness -0.50

Activity Summary

Kd 2 meas. best 8.04

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M2
CHEMBL211
Kd 8.04 8.04 9.1 1
Muscarinic acetylcholine receptor M3
CHEMBL5498
Kd 7.74 7.74 18.2 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
9767650 10.1021/jm981038d Muscarinic acetylcholine receptor M2 1
9767650 10.1021/jm981038d Muscarinic acetylcholine receptor M3 1

Data from ChEMBL 36 via Core Engine