Compound Detail
CHEMBL3350527
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N=C(N)c1ccc(CS(=O)(=O)F)cc1.Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2O)c(=O)n1
Basic Information
| ChEMBL ID | CHEMBL3350527 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SVAFJOSCKBLWLZ-JBMRGDGGSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
459.5
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| L1210 CHEMBL386 | IC50 | 8.0 | 7.6667 | 10.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| L1210 | IC50 | = | 10.0 | nM | 8.0 | Inhibition of L1210 lymphoid leukemia cells 48 hr after administration (length o... | 1527783 |
| L1210 | IC50 | = | 10.0 | nM | 8.0 | Inhibition of L1210 lymphoid leukemia cells 72 hr after administration (length o... | 1527783 |
| L1210 | IC50 | = | 100.0 | nM | 7.0 | Inhibition of L1210 lymphoid leukemia cells 24 hr after administration (length o... | 1527783 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 1527783 | 10.1021/jm00096a006 | L1210 | 3 |
Data from ChEMBL 36 via Core Engine