Compound Detail
CHEMBL3354145
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Basic Information
| ChEMBL ID | CHEMBL3354145 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GWBFFSNCFNCVFV-MEDUHNTESA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
329.3
MW (Da)
3.03
ALogP
4
HBA
1
HBD
64.6
PSA (Ų)
0.88
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| N-acylethanolamine-hydrolyzing acid amidase CHEMBL2034805 | IC50 | 7.96 | 7.96 | 11.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| N-acylethanolamine-hydrolyzing acid amidase | IC50 | = | 10.96 | nM | 7.96 | Inhibition of NAAA in Sprague-Dawley rat lung assessed as inhibition of hydrolys... | 25380517 |
| N-acylethanolamine-hydrolyzing acid amidase | IC50 | = | 11.0 | nM | 7.96 | Inhibition of NAAA in Sprague-Dawley rat lung assessed as inhibition of hydrolys... | 25380517 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 25380517 | 10.1021/jm501455s | N-acylethanolamine-hydrolyzing acid amidase | 2 |
Data from ChEMBL 36 via Core Engine