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Target Snapshot

CHEMBL2034805 Target Snapshot

N-acylethanolamine-hydrolyzing acid amidase · SINGLE PROTEIN · Rattus norvegicus

227Compounds
36Assays
0Approved Drugs
321.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q5KTC7. Use UniProt Q5KTC7 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q5KTC7 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats N-acylethanolamine-hydrolyzing acid amidase as ChEMBL target CHEMBL2034805, mapped to UniProt Q5KTC7. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
N-acylethanolamine-hydrolyzing acid amidase
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-14
ChEMBL target ID
CHEMBL2034805
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q5KTC7
N-acylethanolamine-hydrolyzing acid amidase
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether N-acylethanolamine-hydrolyzing acid amidase is the right protein anchor across sources, using UniProt Q5KTC7 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelN-acylethanolamine-hydrolyzing acid amidase
UniProt AccessionQ5KTC7
Component TypeProtein
Sequence Length362 aa

N-acylethanolamine-hydrolyzing acid amidase

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as N-acylethanolamine-hydrolyzing acid amidase, mapped to UniProt Q5KTC7. Sequence length is 362 aa.

Mapped IDQ5KTC7
Review nameN-acylethanolamine-hydrolyzing acid amidase
OrganismRattus norvegicus
Assay Mix

Activity Type Distribution

IC50321.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3354144 8.18 IC50 6.607 Preclinical
CHEMBL2419814 8.15 IC50 7.0 Preclinical
CHEMBL4215669 8.05 IC50 9.0 Preclinical
CHEMBL3354145 7.96 IC50 10.96 Preclinical
CHEMBL2419830 7.89 IC50 13.0 Preclinical
CHEMBL3354153 7.89 IC50 12.88 Preclinical
CHEMBL3770726 7.89 IC50 13.0 Preclinical
CHEMBL3354150 7.82 IC50 15.0 Preclinical
CHEMBL3353551 7.81 IC50 15.49 Preclinical
CHEMBL2419811 7.8 IC50 16.0 Preclinical
Distribution

pChEMBL Value Distribution

38
5.0
39
5.5
38
6.0
38
6.5
31
7.0
43
7.5
9
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

36
Total Assays
165
Tested Compounds
2
Assay Types
Binding — 32 assays, 165 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 20 90 5.8
single protein format 12 75 6.7
ADME — 4 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 4 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine