Compound Detail
CHEMBL335717
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Basic Information
| ChEMBL ID | CHEMBL335717 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OQFHCZONVRWBLQ-JZJYNLBNSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
313.4
MW (Da)
2.89
ALogP
5
HBA
1
HBD
84.7
PSA (Ų)
0.44
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 4.09
IC50 1 meas. best 5.11
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Thromboxane A2 receptor CHEMBL2069 | IC50 | 5.11 | 5.11 | 7700.0 | 1 |
| Homo sapiens CHEMBL372 | EC50 | 4.09 | 4.09 | 81000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Thromboxane A2 receptor | IC50 | = | 7700.0 | nM | 5.11 | TXA2 receptor antagonism, measured by the displacement of [3H]SQ29,548 from the ... | 8831771 |
| Homo sapiens | EC50 | = | 81000.0 | nM | 4.09 | Inhibition of collagen-induced platelet aggregation in human platelet rich plasm... | 8831771 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8831771 | 10.1021/jm960341g | Thromboxane A2 receptor | 1 |
| 8831771 | 10.1021/jm960341g | Thromboxane-A synthase | 1 |
| 8831771 | 10.1021/jm960341g | Homo sapiens | 1 |
Data from ChEMBL 36 via Core Engine