Compound Detail
CHEMBL3357691
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Basic Information
| ChEMBL ID | CHEMBL3357691 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | REQUPDWBGITKAD-UHFFFAOYSA-N |
6
Targets
6
Activities
2
Assay Types
1
PK Parameters
6
Publications
0
Known Names
Molecular Properties
474.5
MW (Da)
3.32
ALogP
6
HBA
1
HBD
70.5
PSA (Ų)
0.67
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.52
EC50 2 meas. best 7.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glycylpeptide N-tetradecanoyltransferase CHEMBL3988596 | IC50 | 8.52 | 8.52 | 3.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 8.52 | 8.52 | 3.0 | 1 |
| Trypanosoma brucei CHEMBL612849 | EC50 | 7.7 | 7.7 | 20.0 | 1 |
| Glycylpeptide N-tetradecanoyltransferase CHEMBL3988591 | IC50 | 6.57 | 6.57 | 270.0 | 1 |
| Glycylpeptide N-tetradecanoyltransferase 1 CHEMBL2593 | IC50 | 6.41 | 6.41 | 390.0 | 1 |
| MRC5 CHEMBL614181 | EC50 | 4.5 | 4.5 | 31400.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 0.1 | mL.min-1.g-1 | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 3.0 | nM | 8.52 | Inhibition of Trypanosoma brucei N-myristoyltransferase assessed as transfer of ... | 25412409 |
| Glycylpeptide N-tetradecanoyltransferase | IC50 | = | 3.0 | nM | 8.52 | Enzyme Inhibition Assay: Measurements were performed using a modification of the... | - |
| Trypanosoma brucei | EC50 | = | 20.0 | nM | 7.7 | Antitrypanosomal activity against Trypanosoma brucei BSF427 expressing VSG118 in... | 25412409 |
| Glycylpeptide N-tetradecanoyltransferase | IC50 | = | 270.0 | nM | 6.57 | Enzyme Inhibition Assay: Measurements were performed using a modification of the... | - |
| Glycylpeptide N-tetradecanoyltransferase 1 | IC50 | = | 390.0 | nM | 6.41 | Inhibition of human N-myristoyltransferase 1 assessed as transfer of [3H]-myrist... | 25412409 |
| MRC5 | EC50 | = | 31400.0 | nM | 4.5 | Antiproliferative activity against human MRC5 cells assessed as reduction cell v... | 25412409 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 25412409 | 10.1021/jm500809c | Unchecked | 2 |
| 25412409 | 10.1021/jm500809c | Glycylpeptide N-tetradecanoyltransferase 1 | 1 |
| 25412409 | 10.1021/jm500809c | Trypanosoma brucei | 1 |
| 25412409 | 10.1021/jm500809c | MRC5 | 1 |
| 25412409 | 10.1021/jm500809c | Mus musculus | 1 |
| 25412409 | 10.1021/jm500809c | Liver | 1 |
Data from ChEMBL 36 via Core Engine