Compound Detail
CHEMBL339922
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Basic Information
| ChEMBL ID | CHEMBL339922 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LOXZGCRYBAKNDQ-UHFFFAOYSA-N |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
378.5
MW (Da)
4.36
ALogP
3
HBA
1
HBD
41.6
PSA (Ų)
0.81
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.69
EC50 1 meas. best 7.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Delta-type opioid receptor CHEMBL236 | IC50 | 8.69 | 8.69 | 2.0 | 1 |
| Delta-type opioid receptor CHEMBL236 | EC50 | 7.92 | 7.92 | 12.1 | 1 |
| Mu-type opioid receptor CHEMBL233 | IC50 | 5.26 | 5.26 | 5440.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Delta-type opioid receptor | IC50 | = | 2.04 | nM | 8.69 | Binding affinity on cloned opioid receptor delta 1 in human HEK293S cells using ... | 11052794 |
| Delta-type opioid receptor | EC50 | = | 12.1 | nM | 7.92 | Effective concentration as delta agonist potency using [35S]GTP-gamma-S binding ... | 11052794 |
| Mu-type opioid receptor | IC50 | = | 5440.0 | nM | 5.26 | Binding affinity on cloned opioid receptor mu 1 in human HEK293S cells using [12... | 11052794 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11052794 | 10.1021/jm000229p | Delta-type opioid receptor | 3 |
| 11052794 | 10.1021/jm000229p | Mu-type opioid receptor | 1 |
| 11052794 | 10.1021/jm000229p | Kappa-type opioid receptor | 1 |
| 11052794 | 10.1021/jm000229p | Opioid receptors; mu & delta | 1 |
| 11052794 | 10.1021/jm000229p | Opioid receptors; delta & kappa | 1 |
Data from ChEMBL 36 via Core Engine