Compound Detail
CHEMBL3401362
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL3401362 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RCDBNYNKFLYGLH-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
255.3
MW (Da)
1.92
ALogP
5
HBA
3
HBD
100.7
PSA (Ų)
0.62
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.9
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 4.9 | 4.9 | 12650.0 | 1 |
| Fibroblast growth factor receptor 2 CHEMBL4142 | IC50 | 4.75 | 4.75 | 17710.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 | IC50 | = | 12650.0 | nM | 4.9 | Inhibition of FGFR1 (unknown origin) after 90 mins by TR-FRET assay | 25736993 |
| Fibroblast growth factor receptor 2 | IC50 | = | 17710.0 | nM | 4.75 | Inhibition of FGFR2 (unknown origin) after 90 mins by TR-FRET assay | 25736993 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 25736993 | 10.1016/j.bmcl.2015.02.010 | Fibroblast growth factor receptor 4 | 1 |
| 25736993 | 10.1016/j.bmcl.2015.02.010 | Fibroblast growth factor receptor 3 | 1 |
| 25736993 | 10.1016/j.bmcl.2015.02.010 | Fibroblast growth factor receptor 2 | 1 |
| 25736993 | 10.1016/j.bmcl.2015.02.010 | Fibroblast growth factor receptor 1 | 1 |
Data from ChEMBL 36 via Core Engine