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Compound Detail

CHEMBL3402228

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C[C@H]1[C@@H](O)CCN1c1ccc(C#N)c2ccccc12

Basic Information

ChEMBL ID CHEMBL3402228
Phase Preclinical
Structure Type MOL
InChI Key LWQKZNNGOSPTCG-ZBEGNZNMSA-N
1
Targets
4
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

252.3
MW (Da)
2.67
ALogP
3
HBA
1
HBD
47.3
PSA (Ų)
0.85
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C16H16N2O
MW 252.32
Aromatic Rings 2
Heavy Atoms 19
NP-Likeness -0.07

Activity Summary

EC50 2 meas. best 9.6
IC50 2 meas. best 8.66

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Androgen receptor
CHEMBL1871
EC50 9.6 9.545 0.2 2
Androgen receptor
CHEMBL1871
IC50 8.66 8.64 2.2 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
25862209 10.1016/j.bmc.2015.03.032 Rattus norvegicus 9
25862209 10.1016/j.bmc.2015.03.032 Androgen receptor 2
35786895 10.1021/acs.jmedchem.2c00716 Androgen receptor 2

Data from ChEMBL 36 via Core Engine