Compound Detail
CHEMBL3402758
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Basic Information
| ChEMBL ID | CHEMBL3402758 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UTRKTKXZUOHEGE-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
442.5
MW (Da)
3.14
ALogP
8
HBA
0
HBD
86.0
PSA (Ų)
0.37
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Hepatocyte growth factor receptor CHEMBL3717 | IC50 | 8.0 | 7.775 | 10.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Hepatocyte growth factor receptor | IC50 | = | 10.0 | nM | 8.0 | Inhibition of GST-His6-tagged recombinant human c-Met kinase domain (956 to 1390... | 25736998 |
| Hepatocyte growth factor receptor | IC50 | = | 28.0 | nM | 7.55 | Inhibition of c-Met kinase in human A549 cells assessed as inhibition of phospho... | 25736998 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 25736998 | 10.1016/j.bmcl.2015.02.002 | Hepatocyte growth factor receptor | 2 |
| 25736998 | 10.1016/j.bmcl.2015.02.002 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine