Compound Detail
CHEMBL340724
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Basic Information
| ChEMBL ID | CHEMBL340724 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GNWZLSOWHKZQEB-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
357.5
MW (Da)
3.70
ALogP
3
HBA
1
HBD
35.6
PSA (Ų)
0.84
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.01
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Delta-type opioid receptor CHEMBL236 | IC50 | 7.01 | 7.01 | 98.4 | 1 |
| Mu-type opioid receptor CHEMBL233 | IC50 | 6.73 | 6.73 | 185.0 | 1 |
| Kappa-type opioid receptor CHEMBL237 | IC50 | 6.14 | 6.14 | 724.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Delta-type opioid receptor | IC50 | = | 98.4 | nM | 7.01 | Binding affinity against human opioid receptor delta 1 using [125I]-[D-Ala2]-del... | 11052793 |
| Mu-type opioid receptor | IC50 | = | 185.0 | nM | 6.73 | Binding affinity against cloned human Opioid receptor mu 1 using [125I]FK33824 a... | 11052793 |
| Kappa-type opioid receptor | IC50 | = | 724.0 | nM | 6.14 | Binding affinity against cloned human Opioid receptor kappa 1 using [125I]-D-Pro... | 11052793 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11052793 | 10.1021/jm000228x | Delta-type opioid receptor | 1 |
| 11052793 | 10.1021/jm000228x | Mu-type opioid receptor | 1 |
| 11052793 | 10.1021/jm000228x | Kappa-type opioid receptor | 1 |
| 11052793 | 10.1021/jm000228x | Opioid receptors; mu & delta | 1 |
Data from ChEMBL 36 via Core Engine