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Compound Detail

CHEMBL3417242

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Nc1ccn([C@@H]2O[C@@](CO)(CF)[C@@H](O)[C@H]2F)c(=O)n1

Basic Information

ChEMBL ID CHEMBL3417242
Phase Preclinical
Structure Type MOL
InChI Key XUUFKRXJQUHSNO-IBCQBUCCSA-N
1
Targets
1
Activities
1
Assay Types
6
PK Parameters
7
Publications
0
Known Names

Molecular Properties

277.2
MW (Da)
-1.25
ALogP
7
HBA
3
HBD
110.6
PSA (Ų)
0.64
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C10H13F2N3O4
MW 277.23
Aromatic Rings 1
Heavy Atoms 19
NP-Likeness 1.07

Activity Summary

EC50 1 meas. best 6.8

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Respiratory syncytial virus
CHEMBL612679
EC50 6.8 6.8 160.0 1

Pharmacokinetic Data

Parameter Value Units Species
AUC 1540.0 ng.hr.mL-1 Macaca fascicularis
AUC 31835.0 ng.hr.mL-1 Rattus norvegicus
CL 54.3 mL.min-1.kg-1 Macaca fascicularis
CL 2.69 mL.min-1.kg-1 Rattus norvegicus
T1/2 7.66 hr Macaca fascicularis
T1/2 9.49 hr Rattus norvegicus

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
25667954 10.1021/jm5017279 ADMET 5
25667954 10.1021/jm5017279 Cynomolgus monkey 5
25667954 10.1021/jm5017279 Rattus norvegicus 5
25667954 10.1021/jm5017279 Lung 2
25667954 10.1021/jm5017279 Respiratory syncytial virus 1
25667954 10.1021/jm5017279 HeLa 1
25667954 10.1021/jm5017279 A549 1

Data from ChEMBL 36 via Core Engine