Assay Detail
Functional
CHEMBL3418701
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Antiviral activity against Respiratory syncytial virus subgenomic replicon system in 395 HeLa cells assessed as reduction in viral replication after 7 days by renilla luciferase assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Respiratory syncytial virus |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Respiratory syncytial virus (CHEMBL612679) ↗| Type | ORGANISM |
| Organism | Respiratory syncytial virus |
Publication
Discovery of 4'-chloromethyl-2'-deoxy-3',5'-di-O-isobutyryl-2'-fluorocytidine (ALS-8176), a first-in-class RSV polymerase inhibitor for treatment of human respiratory syncytial virus infection.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 32 | 6.38 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3417262 | — | — | 1 | 7.52 |
| CHEMBL3417264 | — | — | 1 | 7.40 |
| CHEMBL3417257 | — | — | 1 | 7.40 |
| CHEMBL3417266 | — | — | 1 | 7.22 |
| CHEMBL3417265 | — | — | 1 | 7.00 |
| CHEMBL3417259 | — | — | 1 | 6.89 |
| CHEMBL3417243 | ALS-8112 | -1.0 | 1 | 6.82 |
| CHEMBL3417267 | — | — | 1 | 6.80 |
| CHEMBL3417242 | — | — | 1 | 6.80 |
| CHEMBL483357 | — | — | 1 | 6.72 |
| CHEMBL3417260 | — | — | 1 | 6.66 |
| CHEMBL3417263 | — | — | 1 | 6.66 |
| CHEMBL3417258 | LUMICITABINE | 2.0 | 1 | 6.58 |
| CHEMBL3417268 | — | — | 1 | 6.57 |
| CHEMBL3417261 | — | — | 1 | 6.55 |
| CHEMBL3417246 | — | — | 1 | 6.38 |
| CHEMBL3417244 | — | — | 1 | 6.32 |
| CHEMBL3417251 | — | — | 1 | 6.29 |
| CHEMBL513181 | — | — | 1 | 6.28 |
| CHEMBL3417250 | — | — | 1 | 6.25 |
| CHEMBL393857 | 4'-AZIDOCYTIDINE | -1.0 | 1 | 6.17 |
| CHEMBL484955 | — | — | 1 | 6.12 |
| CHEMBL3417247 | — | — | 1 | 5.95 |
| CHEMBL3417245 | — | — | 1 | 5.72 |
| CHEMBL3417241 | — | — | 1 | 5.67 |
| CHEMBL3417248 | — | — | 1 | 5.58 |
| CHEMBL3417249 | — | — | 1 | 5.57 |
| CHEMBL3417252 | — | — | 1 | 4.90 |
| CHEMBL3417254 | — | — | 1 | 4.19 |
| CHEMBL3417253 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3417262 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3417264 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3417257 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3417266 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3417265 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3417259 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3417243 | ALS-8112 | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3417267 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3417242 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL483357 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL3417260 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL3417263 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL3417258 | LUMICITABINE | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3417268 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL3417261 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL3417246 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL3417244 | — | EC50 | = | 480.0 | nM | 6.32 |
| CHEMBL3417251 | — | EC50 | = | 510.0 | nM | 6.29 |
| CHEMBL513181 | — | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL3417250 | — | EC50 | = | 560.0 | nM | 6.25 |
| CHEMBL393857 | 4'-AZIDOCYTIDINE | EC50 | = | 670.0 | nM | 6.17 |
| CHEMBL484955 | — | EC50 | = | 750.0 | nM | 6.12 |
| CHEMBL3417247 | — | EC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL3417245 | — | EC50 | = | 1910.0 | nM | 5.72 |
| CHEMBL3417241 | — | EC50 | = | 2140.0 | nM | 5.67 |
| CHEMBL3417248 | — | EC50 | = | 2640.0 | nM | 5.58 |
| CHEMBL3417249 | — | EC50 | = | 2690.0 | nM | 5.57 |
| CHEMBL3417252 | — | EC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL3417254 | — | EC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL3417253 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3417255 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3417256 | — | EC50 | > | 100000.0 | nM | - |