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Compound Detail

CHEMBL342051

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CC1(C)CCOc2ccc(-c3ccc4cc(C(=O)O)ccc4c3)cc21

Basic Information

ChEMBL ID CHEMBL342051
Phase Preclinical
Structure Type MOL
InChI Key OYWXZUTUIPXTRD-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

332.4
MW (Da)
5.27
ALogP
2
HBA
1
HBD
46.5
PSA (Ų)
0.70
QED
1
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H20O3
MW 332.40
Aromatic Rings 3
Heavy Atoms 25
NP-Likeness 0.28

Activity Summary

Ki 3 meas. best 6.68

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Retinoic acid receptor beta
CHEMBL2008
Ki 6.68 6.68 210.0 1
Retinoic acid receptor gamma
CHEMBL2003
Ki 6.07 6.07 860.0 1
Retinoic acid receptor alpha
CHEMBL2055
Ki 5.07 5.07 8500.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
8544175 10.1021/jm00026a006 Retinoic acid receptor alpha 1
8544175 10.1021/jm00026a006 Retinoic acid receptor beta 1
8544175 10.1021/jm00026a006 Retinoic acid receptor gamma 1
8544175 10.1021/jm00026a006 F9 1

Data from ChEMBL 36 via Core Engine