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Assay Detail

CHEMBL798022

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to retinoic acid receptor (RAR) gamma using [3H]CD 367 as radioligand
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Retinoic acid receptor gamma (CHEMBL2003)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis, structure-affinity relationships, and biological activities of ligands binding to retinoic acid receptor subtypes.
Charpentier B, Bernardon JM, Eustache J, Millois C, Martin B, Michel S, Shroot B.
J Med Chem (1995) 38 : 4993 -5006
PubMed 8544175 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 25 7.24 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL36768 1 8.70
CHEMBL38 TRETINOIN 4.0 1 8.52
CHEMBL275311 1 8.30
CHEMBL74826 1 7.89
CHEMBL146646 1 7.70
CHEMBL345022 1 7.57
CHEMBL356326 1 7.54
CHEMBL146636 1 7.47
CHEMBL25361 1 7.40
CHEMBL421773 1 7.28
CHEMBL357917 1 7.14
CHEMBL1180 O-DEMETHYLATED ADAPALENE 1 7.11
CHEMBL348449 1 7.07
CHEMBL146449 1 7.02
CHEMBL148231 1 6.92
CHEMBL1265 ADAPALENE 4.0 1 6.89
CHEMBL357603 1 6.82
CHEMBL147545 1 6.82
CHEMBL345298 1 6.80
CHEMBL74218 1 6.70
CHEMBL422490 1 6.41
CHEMBL146092 1 6.37
CHEMBL342051 1 6.07
CHEMBL149366 1 -
CHEMBL145911 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL36768 Ki = 2.0 nM 8.70
CHEMBL38 TRETINOIN Ki = 3.0 nM 8.52
CHEMBL275311 Ki = 5.0 nM 8.30
CHEMBL74826 Ki = 13.0 nM 7.89
CHEMBL146646 Ki = 20.0 nM 7.70
CHEMBL345022 Ki = 27.0 nM 7.57
CHEMBL356326 Ki = 29.0 nM 7.54
CHEMBL146636 Ki = 34.0 nM 7.47
CHEMBL25361 Ki = 40.0 nM 7.40
CHEMBL421773 Ki = 53.0 nM 7.28
CHEMBL357917 Ki = 72.0 nM 7.14
CHEMBL1180 O-DEMETHYLATED ADAPALENE Ki = 77.0 nM 7.11
CHEMBL348449 Ki = 85.0 nM 7.07
CHEMBL146449 Ki = 95.0 nM 7.02
CHEMBL148231 Ki = 121.0 nM 6.92
CHEMBL1265 ADAPALENE Ki = 130.0 nM 6.89
CHEMBL357603 Ki = 153.0 nM 6.82
CHEMBL147545 Ki = 151.0 nM 6.82
CHEMBL345298 Ki = 160.0 nM 6.80
CHEMBL74218 Ki = 200.0 nM 6.70
CHEMBL422490 Ki = 386.0 nM 6.41
CHEMBL146092 Ki = 426.0 nM 6.37
CHEMBL342051 Ki = 860.0 nM 6.07
CHEMBL149366 Ki > 10000.0 nM -
CHEMBL145911 Ki > 10000.0 nM -