Compound Detail
CHEMBL348449
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Basic Information
| ChEMBL ID | CHEMBL348449 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QTSPAYWZFDRSJK-ACCUITESSA-N |
4
Targets
4
Activities
2
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
310.4
MW (Da)
4.95
ALogP
2
HBA
2
HBD
57.5
PSA (Ų)
0.79
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 7.07
IC50 1 meas. best 6.16
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Retinoic acid receptor gamma CHEMBL2003 | Ki | 7.07 | 7.07 | 85.0 | 1 |
| Retinoic acid receptor beta CHEMBL2008 | Ki | 6.98 | 6.98 | 105.0 | 1 |
| F9 CHEMBL614296 | IC50 | 6.16 | 6.16 | 700.0 | 1 |
| Retinoic acid receptor alpha CHEMBL2055 | Ki | 6.08 | 6.08 | 834.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Retinoic acid receptor gamma | Ki | = | 85.0 | nM | 7.07 | Binding affinity to retinoic acid receptor (RAR) gamma using [3H]CD 367 as radio... | 8544175 |
| Retinoic acid receptor beta | Ki | = | 105.0 | nM | 6.98 | Binding affinity to retinoic acid receptor beta using [3H]CD 367 as radioligand | 8544175 |
| F9 | IC50 | = | 700.0 | nM | 6.16 | Compound was evaluated for its inhibitory activity against F9 murine teratocarci... | 8544175 |
| Retinoic acid receptor alpha | Ki | = | 834.0 | nM | 6.08 | Binding affinity to retinoic acid receptor alpha using [3H]CD 367 as radioligand | 8544175 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8544175 | 10.1021/jm00026a006 | F9 | 2 |
| 8544175 | 10.1021/jm00026a006 | Retinoic acid receptor alpha | 1 |
| 8544175 | 10.1021/jm00026a006 | Retinoic acid receptor beta | 1 |
| 8544175 | 10.1021/jm00026a006 | Retinoic acid receptor gamma | 1 |
Data from ChEMBL 36 via Core Engine