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Compound Detail

CHEMBL422490

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O=C(O)c1ccc2cc(-c3ccc(CO)c(C45CC6CC(CC(C6)C4)C5)c3)ccc2c1

Basic Information

ChEMBL ID CHEMBL422490
Phase Preclinical
Structure Type MOL
InChI Key FICUSZQKSIPECZ-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

412.5
MW (Da)
6.17
ALogP
2
HBA
2
HBD
57.5
PSA (Ų)
0.54
QED
1
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C28H28O3
MW 412.53
Aromatic Rings 3
Heavy Atoms 31
NP-Likeness 0.19

Activity Summary

Ki 2 meas. best 6.81

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Retinoic acid receptor beta
CHEMBL2008
Ki 6.81 6.81 156.0 1
Retinoic acid receptor gamma
CHEMBL2003
Ki 6.41 6.41 386.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
8544175 10.1021/jm00026a006 Retinoic acid receptor alpha 1
8544175 10.1021/jm00026a006 Retinoic acid receptor beta 1
8544175 10.1021/jm00026a006 Retinoic acid receptor gamma 1
8544175 10.1021/jm00026a006 F9 1

Data from ChEMBL 36 via Core Engine