Compound Detail
CHEMBL3422816
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Basic Information
| ChEMBL ID | CHEMBL3422816 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FSMSZUNLYUQVHH-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
311.3
MW (Da)
2.87
ALogP
4
HBA
2
HBD
95.7
PSA (Ų)
0.67
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.94
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily M member 8 CHEMBL5011 | IC50 | 4.94 | 4.94 | 11400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily M member 8 | IC50 | = | 11400.0 | nM | 4.94 | Antagonist activity against rat TRPM8 expressed in HEK293 cells assessed as inhi... | 25935641 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 25935641 | 10.1016/j.bmcl.2015.04.032 | Transient receptor potential cation channel subfamily M member 8 | 3 |
Data from ChEMBL 36 via Core Engine