Compound Detail
CHEMBL3426945
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Basic Information
| ChEMBL ID | CHEMBL3426945 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GMNNTQPTKYJUKQ-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
412.2
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Interleukin-8 receptors, CXCR1/CXCR2 CHEMBL2096909 | IC50 | 7.1 | 7.1 | 80.0 | 1 |
| C-X-C chemokine receptor type 2 CHEMBL2434 | IC50 | 7.1 | 7.1 | 79.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Interleukin-8 receptors, CXCR1/CXCR2 | IC50 | = | 80.0 | nM | 7.1 | Antagonist activity at CXCR1/CXCR2 in human PMN cells assessed as inhibition of ... | 25933594 |
| C-X-C chemokine receptor type 2 | IC50 | = | 79.0 | nM | 7.1 | In Vitro Inhibition Assay: An in vitro assay showed inhibition of CXCR2-mediated... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 25933594 | 10.1016/j.bmcl.2015.04.041 | Interleukin-8 receptors, CXCR1/CXCR2 | 1 |
Data from ChEMBL 36 via Core Engine