Compound Detail
CHEMBL343718
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL343718 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UUAWXQCKXNEYJL-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
318.4
MW (Da)
0.26
ALogP
6
HBA
2
HBD
95.9
PSA (Ų)
0.61
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.76
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Stromelysin-1 CHEMBL283 | IC50 | 6.76 | 6.76 | 175.0 | 1 |
| Interstitial collagenase CHEMBL332 | IC50 | 6.2 | 6.2 | 638.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Stromelysin-1 | IC50 | = | 175.0 | nM | 6.76 | In vitro inhibitory activity against matrix metalloprotease-3. | 10579818 |
| Interstitial collagenase | IC50 | = | 638.0 | nM | 6.2 | In vitro inhibitory activity against truncated collagenase-1 (matrix metalloprot... | 10579818 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10579818 | 10.1021/jm990330y | Interstitial collagenase | 1 |
| 10579818 | 10.1021/jm990330y | Stromelysin-1 | 1 |
Data from ChEMBL 36 via Core Engine