Compound Detail
CHEMBL346187
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Basic Information
| ChEMBL ID | CHEMBL346187 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SQDFCMSNQXZXAS-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
267.1
MW (Da)
0.57
ALogP
5
HBA
3
HBD
96.4
PSA (Ų)
0.74
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas.
IC50 1 meas. best 4.77
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA CHEMBL2093871 | IC50 | 4.77 | 4.77 | 17000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA | IC50 | = | 17000.0 | nM | 4.77 | In vitro binding affinity for Ionotropic glutamate receptor AMPA site was determ... | 9046343 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9046343 | 10.1021/jm9607212 | ADMET | 3 |
| 9046343 | 10.1021/jm9607212 | Glutamate receptor ionotropic, AMPA | 1 |
| 9046343 | 10.1021/jm9607212 | Rattus norvegicus | 1 |
Data from ChEMBL 36 via Core Engine