Assay Detail
Binding
CHEMBL697361
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In vitro binding affinity for Ionotropic glutamate receptor AMPA site was determined using [3H]AMPA as radioligand in rat cortex
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, AMPA (CHEMBL2093871) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
AMPA receptor agonists: synthesis, protolytic properties, and pharmacology of 3-isothiazolol bioisosteres of glutamic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.88 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13378 | (R,S)-AMPA | — | 1 | 7.40 |
| CHEMBL151487 | — | — | 1 | 6.20 |
| CHEMBL73698 | — | — | 1 | 6.19 |
| CHEMBL9907 | — | — | 1 | 5.82 |
| CHEMBL358019 | — | — | 1 | 5.75 |
| CHEMBL113180 | — | — | 1 | 5.68 |
| CHEMBL347973 | — | — | 1 | 5.24 |
| CHEMBL346187 | — | — | 1 | 4.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13378 | (R,S)-AMPA | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL151487 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL73698 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL9907 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL358019 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL113180 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL347973 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL346187 | — | IC50 | = | 17000.0 | nM | 4.77 |