Compound Detail
CHEMBL358019
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL358019 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OPKPBXNFBGXDSB-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
202.2
MW (Da)
0.11
ALogP
5
HBA
3
HBD
96.4
PSA (Ų)
0.65
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 4.82
IC50 1 meas. best 5.75
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA CHEMBL2093871 | IC50 | 5.75 | 5.75 | 1800.0 | 1 |
| Rattus norvegicus CHEMBL376 | EC50 | 4.82 | 4.82 | 15000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA | IC50 | = | 1800.0 | nM | 5.75 | In vitro binding affinity for Ionotropic glutamate receptor AMPA site was determ... | 9046343 |
| Rattus norvegicus | EC50 | = | 15000.0 | nM | 4.82 | Effective concentration evaluated in electrophysiological rat cortical slice mod... | 9046343 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9046343 | 10.1021/jm9607212 | ADMET | 3 |
| 9046343 | 10.1021/jm9607212 | Glutamate receptor ionotropic, AMPA | 1 |
| 9046343 | 10.1021/jm9607212 | Rattus norvegicus | 1 |
| 9046343 | 10.1021/jm9607212 | Mus musculus | 1 |
Data from ChEMBL 36 via Core Engine