Assay Detail
Functional
CHEMBL799513
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Effective concentration evaluated in electrophysiological rat cortical slice model
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
AMPA receptor agonists: synthesis, protolytic properties, and pharmacology of 3-isothiazolol bioisosteres of glutamic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 4.85 | 5.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13378 | (R,S)-AMPA | — | 1 | 5.46 |
| CHEMBL151487 | — | — | 1 | 4.85 |
| CHEMBL358019 | — | — | 1 | 4.82 |
| CHEMBL73698 | — | — | 1 | 4.66 |
| CHEMBL113180 | — | — | 1 | 4.47 |
| CHEMBL9907 | — | — | 1 | - |
| CHEMBL346187 | — | — | 1 | - |
| CHEMBL347973 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13378 | (R,S)-AMPA | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL151487 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL358019 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL73698 | — | EC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL113180 | — | EC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL9907 | — | EC50 | = | 370000.0 | nM | - |
| CHEMBL346187 | — | EC50 | = | 500000.0 | nM | - |
| CHEMBL347973 | — | EC50 | = | 370000.0 | nM | - |