Compound Detail
CHEMBL346331
NORMETHADONE 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL346331 |
| Name | NORMETHADONE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | WCJFBSYALHQBSK-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
6
Publications
10
Known Names
1
Indications
Molecular Properties
295.4
MW (Da)
3.90
ALogP
2
HBA
0
HBD
20.3
PSA (Ų)
0.77
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Indications
Cough
ATC Classification
R05DA06
normethadone
Level 1: RESPIRATORY SYSTEM
Level 2: COUGH AND COLD PREPARATIONS
Activity Summary
Ki 3 meas. best 7.45
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mu-type opioid receptor CHEMBL233 | Ki | 7.45 | 7.45 | 35.9 | 1 |
| D(3) dopamine receptor CHEMBL234 | Ki | 5.37 | 5.37 | 4270.0 | 1 |
| D(2) dopamine receptor CHEMBL217 | Ki | 4.46 | 4.46 | 34900.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mu-type opioid receptor | Ki | = | 35.9 | nM | 7.45 | Displacement of [3H]DAMGO from human mu opioid receptor expressed in HEK293 cell... | 34011153 |
| D(3) dopamine receptor | Ki | = | 4270.0 | nM | 5.37 | Displacement of [3H]-N-methylspiperone from human dopamine D3 receptor expressed... | 34011153 |
| D(2) dopamine receptor | Ki | = | 34900.0 | nM | 4.46 | Displacement of [3H]-N-methylspiperone from human dopamine D2 receptor expressed... | 34011153 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| 7097722 | 10.1021/jm00348a016 | Mu-type opioid receptor | 1 |
| 34011153 | 10.1021/acs.jmedchem.1c00611 | D(2) dopamine receptor | 1 |
| 34011153 | 10.1021/acs.jmedchem.1c00611 | Mu-type opioid receptor | 1 |
| 34011153 | 10.1021/acs.jmedchem.1c00611 | D(3) dopamine receptor | 1 |
| 34011153 | 10.1021/acs.jmedchem.1c00611 | D(4) dopamine receptor | 1 |
Data from ChEMBL 36 via Core Engine