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Compound Detail

CHEMBL348215

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CCOC(=O)Cc1c(N)nc(N)nc1OCCOCP(=O)(O)O

Basic Information

ChEMBL ID CHEMBL348215
Phase Preclinical
Structure Type MOL
InChI Key GQKNZBNHBMKKBS-UHFFFAOYSA-N
3
Targets
3
Activities
2
Assay Types
0
PK Parameters
8
Publications
0
Known Names

Molecular Properties

350.3
MW (Da)
-0.72
ALogP
9
HBA
4
HBD
180.1
PSA (Ų)
0.25
QED
0
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C11H19N4O7P
MW 350.27
Aromatic Rings 1
Heavy Atoms 23
NP-Likeness -0.55

Activity Summary

EC50 2 meas. best 4.46
IC50 1 meas. best 9.52

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Human immunodeficiency virus 1
CHEMBL378
IC50 9.52 9.52 0.3 1
Moloney murine sarcoma virus
CHEMBL613501
EC50 4.46 4.46 35000.0 1
Human immunodeficiency virus 2
CHEMBL380
EC50 4.11 4.11 78000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
14584956 10.1021/jm030932o NON-PROTEIN TARGET 3
14584956 10.1021/jm030932o Cytomegalovirus 2
14584956 10.1021/jm030932o Human alphaherpesvirus 3 2
14584956 10.1021/jm030932o Human immunodeficiency virus 1 1
14584956 10.1021/jm030932o Human immunodeficiency virus 2 1
14584956 10.1021/jm030932o Moloney murine sarcoma virus 1
14584956 10.1021/jm030932o CCRF-CEM 1
19112024 10.1016/j.bmc.2008.11.075 Human immunodeficiency virus 1 1

Data from ChEMBL 36 via Core Engine