Compound Detail
CHEMBL348794
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Basic Information
| ChEMBL ID | CHEMBL348794 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UYDVNKJJPDMLSG-XTCLZLMSSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
423.5
MW (Da)
4.90
ALogP
4
HBA
2
HBD
96.2
PSA (Ų)
0.51
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 6.15
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Retinoic acid receptor RXR-alpha CHEMBL2061 | EC50 | 6.15 | 6.15 | 713.0 | 1 |
| Retinoic acid receptor RXR-beta CHEMBL1870 | EC50 | 5.86 | 5.86 | 1384.0 | 1 |
| Retinoic acid receptor RXR-gamma CHEMBL2004 | EC50 | 5.86 | 5.86 | 1379.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Retinoic acid receptor RXR-alpha | EC50 | = | 713.0 | nM | 6.15 | Transcriptional activity was evaluated in CV-1 cells transfected with expression... | 10052980 |
| Retinoic acid receptor RXR-beta | EC50 | = | 1384.0 | nM | 5.86 | Transcriptional activity was evaluated in CV-1 cells transfected with expression... | 10052980 |
| Retinoic acid receptor RXR-gamma | EC50 | = | 1379.0 | nM | 5.86 | Transcriptional activity was evaluated in CV-1 cells transfected with expression... | 10052980 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10052980 | 10.1021/jm980621r | Retinoic acid receptor RXR-alpha | 2 |
| 10052980 | 10.1021/jm980621r | Retinoic acid receptor RXR-beta | 2 |
| 10052980 | 10.1021/jm980621r | Retinoic acid receptor RXR-gamma | 2 |
Data from ChEMBL 36 via Core Engine