Compound Detail
CHEMBL350356
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Basic Information
| ChEMBL ID | CHEMBL350356 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CGXREZRUTGTAGJ-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
433.4
MW (Da)
6.46
ALogP
4
HBA
0
HBD
32.3
PSA (Ų)
0.45
QED
1
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 7.75
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Corticotropin-releasing factor receptor 1 CHEMBL1800 | Ki | 7.75 | 7.735 | 18.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Corticotropin-releasing factor receptor 1 | Ki | = | 18.0 | nM | 7.75 | Inhibition of [125I]ovine-CRF binding to corticotropin releasing factor receptor... | 15509177 |
| Corticotropin-releasing factor receptor 1 | Ki | = | 19.0 | nM | 7.72 | Binding affinity for human recombinant corticotropin releasing factor receptor 1 | 10072679 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10072679 | 10.1021/jm980222w | Corticotropin-releasing factor receptor 1 | 1 |
| 15509177 | 10.1021/jm049737f | Corticotropin-releasing factor receptor 1 | 1 |
Data from ChEMBL 36 via Core Engine