Compound Detail
CHEMBL353891
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Basic Information
| ChEMBL ID | CHEMBL353891 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LNCULDPBYGRCCU-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
3
PK Parameters
4
Publications
0
Known Names
Molecular Properties
446.4
MW (Da)
5.24
ALogP
6
HBA
1
HBD
64.9
PSA (Ų)
0.51
QED
1
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 8.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Corticotropin-releasing factor receptor 1 CHEMBL1800 | Ki | 8.1 | 8.1 | 8.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 13.39 | ng.hr.mL-1 | Rattus norvegicus |
| Cmax | 19.9 | nM | Rattus norvegicus |
| F | 7.0 | % | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Corticotropin-releasing factor receptor 1 | Ki | = | 8.0 | nM | 8.1 | Binding affinity to recombinant human Corticotropin releasing factor receptor 1 ... | 10072681 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10072681 | 10.1021/jm980224g | Rattus norvegicus | 3 |
| 10072681 | 10.1021/jm980224g | Corticotropin-releasing factor receptor 1 | 1 |
| 10072681 | 10.1021/jm980224g | ADMET | 1 |
| 10072681 | 10.1021/jm980224g | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine