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Compound Detail

CHEMBL3582258

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CC(Cc1ccccc1-c1ccccc1)C1=NCCN1

Basic Information

ChEMBL ID CHEMBL3582258
Phase Preclinical
Structure Type MOL
InChI Key VKOXICYFEFRTQW-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

264.4
MW (Da)
3.53
ALogP
2
HBA
1
HBD
24.4
PSA (Ų)
0.90
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H20N2
MW 264.37
Aromatic Rings 2
Heavy Atoms 20
NP-Likeness 0.11

Activity Summary

Ki 2 meas. best 6.81

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Nischarin
CHEMBL5221
Ki 6.81 6.81 154.9 1
Adrenergic receptor alpha-2
CHEMBL2093864
Ki 4.1 4.1 79432.8 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
26005521 10.1021/acsmedchemlett.5b00115 Rattus norvegicus 6
26005521 10.1021/acsmedchemlett.5b00115 Unchecked 1
26005521 10.1021/acsmedchemlett.5b00115 Adrenergic receptor alpha-2 1
26005521 10.1021/acsmedchemlett.5b00115 Nischarin 1

Data from ChEMBL 36 via Core Engine