Compound Detail
CHEMBL3582403
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Basic Information
| ChEMBL ID | CHEMBL3582403 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MXCRRKYUQNHWLJ-VMPITWQZSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
207.6
MW (Da)
2.33
ALogP
2
HBA
1
HBD
61.1
PSA (Ų)
0.60
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Monocarboxylate transporter 1 CHEMBL2073709 | IC50 | 6.3 | 6.3 | 500.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Monocarboxylate transporter 1 | IC50 | = | 500.0 | nM | 6.3 | Inhibition of MCT1-mediated lactate transport in rat RBE4 cells incubated for 15... | 26005533 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26005533 | 10.1021/acsmedchemlett.5b00049 | Monocarboxylate transporter 1 | 1 |
Data from ChEMBL 36 via Core Engine