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Compound Detail

CHEMBL3586012

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CC(=O)OCC1=C[C@H]2[C@@H]3C(C)(C)[C@]3(OC(C)=O)[C@H](O)[C@@H](C)[C@]2(O)[C@@H]2C=C(C)C(=O)[C@@]2(O)C1

Basic Information

ChEMBL ID CHEMBL3586012
Phase Preclinical
Structure Type MOL
InChI Key VCQRVYCLJARKLE-XQOWHXTBSA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

448.5
MW (Da)
1.07
ALogP
8
HBA
3
HBD
130.4
PSA (Ų)
0.43
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C24H32O8
MW 448.51
Aromatic Rings 0
Heavy Atoms 32
NP-Likeness 3.02

Activity Summary

EC50 2 meas. best 4.61

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
NON-PROTEIN TARGET
CHEMBL3879801
EC50 4.61 4.61 24600.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
NON-PROTEIN TARGET EC50 = 24600.0 nM 4.61 Antiviral activity against chikungunya virus Indian ocean strain 899 infected in... 25970561

Literature References

PubMed DOI Target Context # Activities
25970561 10.1021/acs.jnatprod.5b00073 Unchecked 3
25970561 10.1021/acs.jnatprod.5b00073 NON-PROTEIN TARGET 1
25970561 10.1021/acs.jnatprod.5b00073 Human immunodeficiency virus 1 1
25970561 10.1021/acs.jnatprod.5b00073 Human immunodeficiency virus 2 1
34403728 10.1016/j.bmcl.2021.128319 MT4 1

Data from ChEMBL 36 via Core Engine