Compound Detail
CHEMBL3586353
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Basic Information
| ChEMBL ID | CHEMBL3586353 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ATEFYIZFSCUCFR-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
2
PK Parameters
6
Publications
0
Known Names
Molecular Properties
406.9
MW (Da)
6.01
ALogP
4
HBA
0
HBD
25.4
PSA (Ų)
0.42
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Prostaglandin E2 receptor EP2 subtype CHEMBL1881 | IC50 | 7.1 | 6.35 | 80.0 | 2 |
| Prostaglandin E2 receptor EP4 subtype CHEMBL1836 | IC50 | 5.5 | 5.5 | 3200.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 399.0 | mL.min-1.g-1 | Rattus norvegicus |
| CL | 399.0 | mL.min-1.g-1 | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Prostaglandin E2 receptor EP2 subtype | IC50 | = | 80.0 | nM | 7.1 | Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 ... | 26061158 |
| Prostaglandin E2 receptor EP2 subtype | IC50 | = | 2500.0 | nM | 5.6 | Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells as... | 26061158 |
| Prostaglandin E2 receptor EP4 subtype | IC50 | = | 3200.0 | nM | 5.5 | Displacement of [3H]-PGE2 from human EP4 receptor overexpressed in human ECV304 ... | 26061158 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26061158 | 10.1021/acs.jmedchem.5b00567 | Liver microsome | 2 |
| 26061158 | 10.1021/acs.jmedchem.5b00567 | Prostaglandin E2 receptor EP2 subtype | 2 |
| 26061158 | 10.1021/acs.jmedchem.5b00567 | Prostaglandin E2 receptor EP3 subtype | 1 |
| 26061158 | 10.1021/acs.jmedchem.5b00567 | Prostaglandin E2 receptor EP4 subtype | 1 |
| 26061158 | 10.1021/acs.jmedchem.5b00567 | Prostaglandin E2 receptor EP1 subtype | 1 |
| 26061158 | 10.1021/acs.jmedchem.5b00567 | Cytochrome P450 3A4 | 1 |
Data from ChEMBL 36 via Core Engine