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Compound Detail

CHEMBL35979

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CCN1c2cc(Cl)c(C)cc2S(=O)(=O)N(C)c2cccnc21

Basic Information

ChEMBL ID CHEMBL35979
Phase Preclinical
Structure Type MOL
InChI Key GJWHNXWLULIKBL-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

337.8
MW (Da)
3.34
ALogP
4
HBA
0
HBD
53.5
PSA (Ų)
0.80
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C15H16ClN3O2S
MW 337.83
Aromatic Rings 2
Heavy Atoms 22
NP-Likeness -1.53

Activity Summary

IC50 1 meas. best 4.32

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
C8166
CHEMBL614533
IC50 4.32 4.32 48000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
C8166 IC50 = 48000.0 nM 4.32 Antiviral activity was evaluated by inhibition of HIV-1 replication in CD4+ lymp... -

Literature References

PubMed DOI Target Context # Activities
- 10.1016/0960-894X(95)00257-T C8166 3

Data from ChEMBL 36 via Core Engine