Assay Detail
Functional
CHEMBL650520
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Antiviral activity was evaluated by inhibition of HIV-1 replication in CD4+ lymphoblastoid cell line infected with HIV/IIIB strain
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | C8166 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and anti HIV-1 activity of new thiadiazepindioxides
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.54 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL293498 | — | — | 1 | 8.82 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.40 |
| CHEMBL36029 | — | — | 1 | 7.50 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 7.40 |
| CHEMBL36080 | — | — | 1 | 7.40 |
| CHEMBL34545 | — | — | 1 | 6.55 |
| CHEMBL35173 | — | — | 1 | 6.48 |
| CHEMBL290582 | — | — | 1 | 6.22 |
| CHEMBL1460 | DIDANOSINE | 4.0 | 1 | 6.00 |
| CHEMBL32971 | — | — | 1 | 5.43 |
| CHEMBL34150 | — | — | 1 | 5.40 |
| CHEMBL422760 | — | — | 1 | 5.16 |
| CHEMBL35979 | — | — | 1 | 4.32 |
| CHEMBL34021 | — | — | 1 | - |
| CHEMBL290796 | — | — | 1 | - |
| CHEMBL284160 | — | — | 1 | - |
| CHEMBL430920 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL293498 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL129 | ZIDOVUDINE | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL36029 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL36080 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL34545 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL35173 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL290582 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1460 | DIDANOSINE | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL32971 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL34150 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL422760 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL35979 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL34021 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL290796 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL284160 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL430920 | — | IC50 | > | 300000.0 | nM | - |