Compound Detail
CHEMBL3603931
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Basic Information
| ChEMBL ID | CHEMBL3603931 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WPIOOGNLSRYEIU-VIFPVBQESA-N |
3
Targets
4
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
193.2
MW (Da)
1.48
ALogP
3
HBA
1
HBD
32.7
PSA (Ų)
0.79
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 8.07
EC50 1 meas. best 5.04
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Neuronal acetylcholine receptor; alpha4/beta2 CHEMBL1907596 | Ki | 8.07 | 8.07 | 8.5 | 1 |
| Neuronal acetylcholine receptor subunit alpha-7 CHEMBL4980 | Ki | 7.54 | 7.54 | 29.0 | 1 |
| Neuronal acetylcholine receptor; alpha3/beta4 CHEMBL1907594 | Ki | 6.99 | 6.99 | 102.0 | 1 |
| Neuronal acetylcholine receptor; alpha3/beta4 CHEMBL1907594 | EC50 | 5.04 | 5.04 | 9200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Neuronal acetylcholine receptor; alpha4/beta2 | Ki | = | 8.5 | nM | 8.07 | Displacement of [3H]epibatidine from alpha4beta2 nAChR in rat cortex membranes b... | 26225816 |
| Neuronal acetylcholine receptor subunit alpha-7 | Ki | = | 29.0 | nM | 7.54 | Displacement of [125I]]-alpha-bungarotoxin from alpha7 nAChR in rat hippocampus ... | 26225816 |
| Neuronal acetylcholine receptor; alpha3/beta4 | Ki | = | 102.0 | nM | 6.99 | Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in HEK293... | 26225816 |
| Neuronal acetylcholine receptor; alpha3/beta4 | EC50 | = | 9200.0 | nM | 5.04 | Agonist activity at human alpha3beta4 nAChR expressed in rat GH4C1 cells assesse... | 26225816 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26225816 | 10.1021/acs.jmedchem.5b00904 | Neuronal acetylcholine receptor; alpha3/beta4 | 3 |
| 26225816 | 10.1021/acs.jmedchem.5b00904 | Neuronal acetylcholine receptor; alpha4/beta2 | 2 |
| 26225816 | 10.1021/acs.jmedchem.5b00904 | Neuronal acetylcholine receptor subunit alpha-7 | 1 |
Data from ChEMBL 36 via Core Engine