Assay Detail
Binding
CHEMBL3607039
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]]-alpha-bungarotoxin from alpha7 nAChR in rat hippocampus membranes by liquid scintillation counting method
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Hippocampus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL4980) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Chemistry and Pharmacology of a Series of Unichiral Analogues of 2-(2-Pyrrolidinyl)-1,4-benzodioxane, Prolinol Phenyl Ether, and Prolinol 3-Pyridyl Ether Designed as α4β2-Nicotinic Acetylcholine Receptor Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 6.01 | 7.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3603931 | — | — | 1 | 7.54 |
| CHEMBL3603941 | — | — | 1 | 7.24 |
| CHEMBL3603929 | — | — | 1 | 6.92 |
| CHEMBL3603930 | — | — | 1 | 6.67 |
| CHEMBL3 | NICOTINE | 4.0 | 1 | 6.63 |
| CHEMBL3603933 | — | — | 1 | 6.49 |
| CHEMBL3603947 | — | — | 1 | 6.41 |
| CHEMBL3603942 | — | — | 1 | 6.13 |
| CHEMBL3603939 | — | — | 1 | 5.94 |
| CHEMBL3603932 | — | — | 1 | 5.92 |
| CHEMBL3603934 | — | — | 1 | 5.46 |
| CHEMBL3603948 | — | — | 1 | 5.21 |
| CHEMBL3603938 | — | — | 1 | 5.05 |
| CHEMBL3603945 | — | — | 1 | 5.03 |
| CHEMBL3603937 | — | — | 1 | 4.82 |
| CHEMBL3603946 | — | — | 1 | 4.67 |
| CHEMBL3603935 | — | — | 1 | - |
| CHEMBL3603936 | — | — | 1 | - |
| CHEMBL3603944 | — | — | 1 | - |
| CHEMBL3603940 | — | — | 1 | - |
| CHEMBL3603943 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3603931 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL3603941 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL3603929 | — | Ki | = | 119.0 | nM | 6.92 |
| CHEMBL3603930 | — | Ki | = | 212.0 | nM | 6.67 |
| CHEMBL3 | NICOTINE | Ki | = | 234.0 | nM | 6.63 |
| CHEMBL3603933 | — | Ki | = | 321.0 | nM | 6.49 |
| CHEMBL3603947 | — | Ki | = | 388.0 | nM | 6.41 |
| CHEMBL3603942 | — | Ki | = | 743.0 | nM | 6.13 |
| CHEMBL3603939 | — | Ki | = | 1150.0 | nM | 5.94 |
| CHEMBL3603932 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL3603934 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL3603948 | — | Ki | = | 6100.0 | nM | 5.21 |
| CHEMBL3603938 | — | Ki | = | 8900.0 | nM | 5.05 |
| CHEMBL3603945 | — | Ki | = | 9400.0 | nM | 5.03 |
| CHEMBL3603937 | — | Ki | = | 15200.0 | nM | 4.82 |
| CHEMBL3603946 | — | Ki | = | 21500.0 | nM | 4.67 |
| CHEMBL3603935 | — | Ki | - | — | - | |
| CHEMBL3603936 | — | Ki | - | — | - | |
| CHEMBL3603944 | — | Ki | - | — | - | |
| CHEMBL3603940 | — | Ki | - | — | - | |
| CHEMBL3603943 | — | Ki | - | — | - |