Compound Detail
CHEMBL361184
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Basic Information
| ChEMBL ID | CHEMBL361184 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UZXOICNXSPXWIT-PABFRNLHSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
364.4
MW (Da)
4.92
ALogP
2
HBA
1
HBD
42.0
PSA (Ų)
0.52
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 8.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Potassium voltage-gated channel subfamily KQT member 2 CHEMBL2985 | EC50 | 8.0 | 8.0 | 10.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Potassium voltage-gated channel subfamily KQT member 2 | EC50 | = | 10.0 | nM | 8.0 | Effect on outward potassium currents in whole-cell patch clamp assay of HEK 293 ... | 15603955 |
| Potassium voltage-gated channel subfamily KQT member 2 | EC50 | = | 10.0 | nM | 8.0 | Induction of mouse KCNQ2 expressed in HEK293 cells at -40 mV holding potential b... | 24070783 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15603955 | 10.1016/j.bmcl.2004.10.065 | Potassium voltage-gated channel subfamily KQT member 2 | 2 |
| 24070783 | 10.1016/j.bmcl.2013.08.092 | Potassium voltage-gated channel subfamily KQT member 2 | 2 |
Data from ChEMBL 36 via Core Engine